Structural and Functional Analysis of Human Cytomegalovirus US3 Protein
نویسندگان
چکیده
منابع مشابه
Analysis of human cytomegalovirus US3 gene products.
Similar to other herpesviruses, human cytomegalovirus remains in the infected host following resolution of the primary infection. The ability to persist in the host after primary infection is believed to be strongly influenced by the ability of HCMV to down-regulate immune recognition of infected cells. One of the genes contributing to immune evasion is the US3 gene. The US3 gene has been shown...
متن کاملIE2 protein is insufficient for transcriptional repression of the human cytomegalovirus US3 promoter.
Expression of the human cytomegalovirus (HCMV) US3 gene is regulated in part by transcriptional repression mediated through a cis-repressive region located between the TATA box and the transcriptional start site. The US3 cis-repressive element has extensive sequence identity with a similar repressive element in UL122-123 (the major immediate-early gene complex). Repression of UL122-123 is media...
متن کاملStructural and Functional Dissection of the Human Cytomegalovirus Immune Evasion Protein US6.
The human cytomegalovirus (HCMV) protein US6 inhibits the transporter associated with antigen processing (TAP). Since TAP transports antigenic peptides into the endoplasmic reticulum for binding to major histocompatibility class I molecules, inhibition of the transporter by HCMV US6 impairs the presentation of viral antigens to cytotoxic T lymphocytes. HCMV US6 inhibits ATP binding by TAP, henc...
متن کاملRhesus cytomegalovirus contains functional homologues of US2, US3, US6, and US11.
Human cytomegalovirus (HCMV) is a paradigm for mechanisms subverting antigen presentation by major histocompatibility complex (MHC) molecules. Due to its limited host range, HCMV cannot be studied in animals. Thus, the in vivo importance of inhibiting antigen presentation for the establishment and maintenance of infection with HCMV is unknown. Rhesus cytomegalovirus (RhCMV) is an emerging anima...
متن کاملStructural proteins of human cytomegalovirus.
At the Community Blood Center our interests have not only been in studying the epidemiology of cytomegalovirus transfusion-associated infection, but we have also involved ourselves in the biochemical characterization of CMV proteins. I will present some of our laboratory's preliminary findings. We worked with extracellular virus isolated in essentially the same manner as Huang et al. (1) except...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Virology
سال: 2004
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.78.1.413-423.2004